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Publikationen

2017

  • Brock B, Kamysek S, Silz J, Trefz P, Schubert JK, Miekisch W. Monitoring of breath VOCs and electrical impedance tomography under pulmonary recruitment in mechanically ventilated patients. J. Breath Res. 11 (2017) 016005 
  • Trefz P, Kamysek S, Fuchs P, Sukul P, Schubert JK, Miekisch W.. Drug detection in breath: non-invasive assessment of illicit or pharmaceutical drugs. J. Breath Res. 11 (2017) 024001
  • Sukul P, Oertel P, Kamysek S and Trefz P. Oral or nasal breathing? Real-time effects of switching sampling route onto exhaled VOC concentrations. J. Breath Res. 11 (2017)Number 2  

  • Obermeier J, Trefz P, Happ J, Staude H, Schubert JK, Fischer D-C, Miekisch W. Exhaled volatile substances mirror clinical conditions in pediatric chronic kidney disease. PLoS One in press.    

2016

  • Sukul P, Schubert JK, Oertel P, Kamysek S, Taunk K, Trefz P, Miekisch W. FEV manoeuvre induced changes in breath VOC compositions: an unconventional view on lung function tests. Scientific Reports 6, Article number: 28029 (2016) doi:10.1038/srep28029    
      
  • Trepesch C, Nitzsche R, Glass A, Kreikemeyer B, Schubert JK, Oehmcke-Hecht S. High intravascular tissue factor—but not extracellular microvesicles—in septic patients is associated with a high SAPS II score. Journal of Intensive Care (2016) 4:34 DOI 10.1186/s40560-016-0160-5

2015

  • Fischer S, Bergmann A, Steffens M, Trefz P, Ziller M, Miekisch W, Schubert JS, Köhler H, Reinhold P. Impact of food intake on in vivo VOC concentrations in exhaled breath assessed in a caprine animal model. J Breath Res. 2015 Dec 15;9(4):047113. doi: 10.1088/1752-7155/9/4/047113.

  • Sukul P, Trefz P, Kamysek S, Schubert JK, Miekisch W. Instant effects of changing body positions on compositions of exhaled breath. J Breath Res. 2015 Nov 19;9(4):047105. doi: 10.1088/1752-7155/9/4/047105.

  • Pleil JD, Beauchamp JD, Miekisch W, Funk WE. Adapting biomarker technologiesto adverse outcome pathways (AOPs) research: current thoughts on using in vivodiscovery for developing in vitro target methods. J Breath Res. 2015 Jul 14;9(3):039001. doi: 10.1088/1752-7155/9/3/039001.

  • Fischer S, Trefz P, Bergmann A, Steffens M, Ziller M, Miekisch W, Schubert JS, Köhler H, Reinhold P. Physiological variability in volatile organic compounds (VOCs) in exhaled breath and released from faeces due to nutrition and somatic growth in a standardized caprine animal model. J Breath Res. 2015 May 14;9(2):027108. doi: 10.1088/1752-7155/9/2/027108.

  • Bergmann A, Trefz P, Fischer S, Klepik K, Walter G, Steffens M, Ziller M, Schubert JK, Reinhold P, Köhler H, Miekisch W. In Vivo Volatile Organic Compound Signatures of Mycobacterium avium subsp. paratuberculosis. PLoS One. 2015 Apr 27;10(4):e0123980. doi: 10.1371/journal.pone.0123980. eCollection 2015.

  • Obermeier J, Trefz P, Wex K, Sabel B, Schubert JK, Miekisch W. Electrochemical sensor system for breath analysis of aldehydes, CO and NO. J Breath Res. 2015 Mar 9;9(1):016008. doi: 10.1088/1752-7155/9/1/016008.

2014

  • Sukul P, Trefz P, Schubert JK, Miekisch W. Immediate effects of breath holding maneuvers onto composition of exhaled breath. J Breath Res. 2014 Sep;8(3):037102. doi: 10.1088/1752-7155/8/3/037102.

  • Miekisch W, Trefz P, Bergmann A, Schubert JK. Microextraction techniques in breath biomarker analysis. Bioanalysis. 2014 May;6(9):1275-91. Review.

  • Amann A, Miekisch W, Schubert J, Buszewski B, Ligor T, Jezierski T, Pleil J, Risby T. Analysis of exhaled breath for disease detection.  Annu Rev Anal Chem (Palo Alto Calif). 2014;7:455-82. doi: 10.1146/annurev-anchem-071213-020043.

  • Amann A, Costello Bde L, Miekisch W, Schubert J, Buszewski B, Pleil J, Ratcliffe N, Risby T. The human volatilome: volatile organic compounds (VOCs) in exhaled breath, skin emanations, urine, feces and saliva. J Breath Res. 2014 Sep;8(3):034001. doi: 10.1088/1752-7155/8/3/034001.

  • Pleil JD, Miekisch W, Stiegel MA, Beauchamp J. Extending breath analysis to the cellular level: current thoughts on the human microbiome and the expression of organic compounds in the human exposome. J Breath Res. 2014 Jun;8(2):029001. doi: 10.1088/1752-7155/8/2/029001.


2013

  • Anthony Alozie, Bernd Westphal, Stephan Kische, Alexander Kaminski, Liliya Paranskaya, Ilkay Bozdag-Turan, Jasmin Ortak, Jochen Schubert, Gustav Steinhoff, Hüseyin Ince. Surgical revision after percutaneous mitral valve repair by edge-to-edge device: when the strategy fails in the highest risk surgical population. European journal of cardio-thoracic surgery: official journal of the European Association for Cardio-thoracic Surgery (Impact Factor: 2.4). 12/2013; DOI:10.1093/ejcts/ezt53
  • Kleeblatt J, Ehlert S, Hölzer J, Sklorz M, Rittgen J, Baumgärtel P, Schubert JK, Zimmermann R. Investigation of the photoionization properties of pharmaceutically relevant substances by resonance-enhanced multiphoton ionization spectroscopy and single-photon ionization spectroscopy using synchrotron radiation. Appl Spectrosc. 2013 Aug;67(8):860-72. doi: 10.1366/13-06988
  • Trefz P, Schmidt M, Oertel P, Obermeier J, Brock B, Kamysek S, Dunkl J, Zimmermann R, Schubert JK, Miekisch W. Continuous real time breath gas monitoring in the clinical environment by proton-transfer-reaction-time of flight-mass spectrometry. Anal Chem. 2013 Nov 5;85(21):10321-9.
  • Trefz P, Koehler H, Klepik K, Moebius P, Schubert J, Reinhold P, Miekisch W. Volatile emissions from Mycobacterium avium subsp. paratuberculosis mirror bacterial growth and enable distinction of different strains. PLoS One. 2013 Oct 8;8(10):e76868. doi: 10.1371/journal.pone.0076868
  • Trefz P, Rösner L, Hein D, Schubert JK, Miekisch W. Evaluation of needle trap micro-extraction and automatic alveolar sampling for point-of-care breath analysis. Anal Bioanal Chem. 2013 Apr;405(10):3105-15.
  • Goerl T, Kischkel S, Sawacki A, Fuchs P, Miekisch W, Schubert JK. Volatile breath biomarkers for patient monitoring during haemodialysis. J Breath Res. 2013 Mar;7(1):017116. doi: 10.1088/1752-7155/7/1/017116. Epub 2013 Feb 27


2012

  • Miekisch W, Herbig, Schubert JK. Data interpretation in breath biomarker research: pitfalls and directions. J. Breath Res. 6 (2012) 036007 (10pp); doi:10.1088/1752-7155/6/3/036007
  • Paranskaya L, D'Ancona G, Bozdag-Turan I, Akin I, Kische S, Turan GR, Divchev D, Rehders T, Westphal B, Schubert J, Nienaber CA, Ince H. Percutaneous mitral valve repair with the MitraClip® system: Perioperative and 1-year follow-up results using standard or multiple clipping strategy. Catheter Cardiovasc Interv. 2012 Jun 28. doi: 10.1002/ccd.24538. [Epub ahead of print]
  • Schubert R, Schwoebel H, Mau-Moeller A, Behrens M, Fuchs P, Sklorz M, Schubert JK, Bruhn S, Miekisch W. Metabolic monitoring and assessment of anaerobic threshold by means of breath biomarkers. Metabolomics 2012; 8. 1069-1080.
  • Kischkel S, Miekisch W, Fuchs P, Schubert JK. Breath analysis during one-lung ventilation in cancer patients. Eur Respir J 2012. doi: 10.1183/09031936.00125411.
  • Hergert SM, Koball S, Machmüller S, Nöldge-Schomburg GEF, Schubert JK, Roesner JP. Vancomycintherapie und Niereninsuffizienz – eine verhängnisvolle Kombination und Ihre Behandlung (Vancomycin treatment and renal failure – a dramatic situation and its management). Anästh Intensivmed 2012;1:46-49.

2011

  • Trefz P, Kischkel S, Hein D, James ES, Schubert JK, Miekisch W. Needle trap micro-extraction for VOC analysis: effects of packing materials and desorption parameters. J Chromatography A. 2011; 1219:29-38.
  • Kamysek S, Fuchs P, Schwoebel H, Roesner JP, Kischkel S, Wolter K, Loeseken C, Schubert JK, Miekisch W. Drug detection in breath: Effects of pulmonary blood flow and cardiac output on propofol exhalation. Anal Bioanal Chem. 2011;401(7):2093-102.
  • Schwöbel HU, Schubert R, Sklorz M, Kischkel S, Zimmermann R, Schubert JK, Miekisch W. Phase resolved real-time breath analysis during exercise by means of smart processing of PTR-MS data. Anal Bioanal Chem. 2011; 401(7):2079-91.

2010

  • Sabel B, Schubert J, Miekisch W, Fuchs P, Kischkel S, Mieth M. Comparison of different preconcentration techniques in breath analysis under real life clinical conditions. Eur J Med Res 2010; 15:1-1.
  • Sponring A, Filipiak W, Ager C, Schubert J, Miekisch W, Amann A, Troppmair J. Analysis of volatile organic compounds (VOCs) in the headspace of NCI-H1666 lung cancer cells. Cancer Biomark. 2010;7(3):153-61.
  • Amann A, Ligor M, Ligor T, Bajtarevic A, Ager C, Pienz M, Denz H, Fiegl M, Hilbe W, Weiss W, Lukas P, Jamnig H, Hackl M, Haidenberger A, Sponring A, Filipiak W, Miekisch W, Schubert J, Troppmair J, Buszewski B. Analysis of exhaled breath for screening of lung cancer patients. Memo 2010; 3:106-112.
  • Olszowy P, Szultka M, Fuchs P, Kegler R, Mundkowski R, Miekisch W, Schubert JK, Boguslaw Buszewski B. New coated SPME fibers for extraction and fast HPLC determination of selected drugs in human blood. J Pharm Biomed Anal. 2010; 53(4):1022-7.
  • Kischkel S, Miekisch W, Sawacki A, Straker EM, Trefz P, Amann A, Schubert JK. Breath biomarkers for lung cancer detection and assessment of smoking related effects - confounding variables, influence of normalization and statistical algorithms. Clin Chim Acta. 2010; 411(21-22):1637-44.
  • Szultka M, Kegler R, Fuchs P, Olszowy P; Miekisch W, Schubert JK, Buszewski B, Mundkowski RG. Polypyrrole solid phase microextraction: a new approach to rapid sample preparation for the monitoring of antibiotic drugs. Anal Chim Acta. 2010; 667(1-2):77-82.
  • Fuchs P, Loeseken C, Schubert JK, Miekisch W. Breath gas aldehydes as biomarkers of lung cancer. Int J Cancer. 2010; 126(11):2663–2670.
  • Mieth M, Schubert J, Gröger T, Sabel B, Kischkel S, Fuchs P, Hein D, Zimmermann R, Miekisch M. Automated Needle Trap Heartcut-GC-MS and Needle Trap comprehensive GCxGC-TOF-MS for Breath Gas Analysis in the Clinical Environment. Anal Chem. 2010; 82(6):2541-51.
  • Filipiak W, Sponring A, Filipiak A, Ager C, Schubert J, Miekisch W, Amann A, Troppmair J.. TD-GC-MS analysis of volatile metabolites of human lung cancer and normal cells in vitro. Cancer Epidemiol Biomarkers Prev. 2010; 19(1): 182-95.
  • Miekisch W, Hengstenberg A, Kischkel S, Beckmann U, Mieth M, Schubert J.K. Construction and evaluation of a versatile CO2 controlled breath collection device. IEEE Sensors Journal. 2010; 10(1):211-215.

Vor 2010

  • King J, Kupferthaler A, Unterkofler K, Koc H, Teschl S, Teschl G, Miekisch W, Schubert JK, Hinterhuber H, Amann A. Isoprene and acetone concentration profiles during exercise on an ergometer. J Breath Res. 2009; 3: 027006 (16pp).
  • Bajtarevic A, Ager C, Pienz M, Klieber M, Schwarz K, Ligor M, Ligor T, Filipiak W, Denz H, Fiegl M, Hilbe W, Weiss W, Lukas P, Jamnig H, Hackl M, Haidenberger A, Buszewski B, Miekisch W, Schubert J, Amann A. Noninvasive detection of lung cancer by analysis of exhaled breath. BMC Cancer. 2009; 9: 348.
  • Buszewski B, Wasiniak B, Ligor T, Nowaczyk J, Olszowy P, Miekisch W, Schubert JK, Amann A. Preparation and characterization of microporous fibers for sample preparation and LC-MS determination of drugs. J Sep Sci. 2009; 32(14):2448-54.
  • Mieth M, Kischkel S, Schubert JK, Hein D, Miekisch W. Multibed Needle Trap Devices for on Site Sampling and Preconcentration of Volatile Breath Biomarkers. Anal Chem. 2009; 81(14):5851-7.
  • Ligor M, Ligor T, Bajtarevic A, Ager C, Pienz M, Klieber M, Denz H, Fiegl M, Hilbe W, Weiss W, Lukas P, Jamnig H, Hackl M, Buszewski B, Miekisch W, Schubert J, Amann A. Determination of volatile organic compounds in exhaled breath of patients with lung cancer using solid phase microextraction and gas chromatography mass spectrometry. Clin Chem Lab Med. 2009; 47(5):550-60.
  • Schwarz K, Pizzini A, Arendack B, Zerlauth K, Filipiak W, Schmid A, Dzien A, Neuner S, Lechleitner M, Scholl-Bürgi S, Miekisch W, Schubert JK, Unterkofler K, Witkovský V, Gastl G, Amann A. Breath acetone - aspects of normal physiology related to age and gender as determined in a PTR-MS study. J. Breath Res. 2009; 3: 027003 (9pp).
  • Sponring A, Filipiak W, Mikoviny T, Ager C, Schubert J, Miekisch W, Amann A, Troppmair J. Release of volatile organic compounds from the lung cancer cell line NCI-H2087 in vitro. Anticancer Res. 2009; 29(1):419-26.
  • Filipiak W, Sponring A, Mikoviny T, Ager C, Schubert J, Miekisch W, Amann A, Troppmair J. Release of volatile organic compounds (VOCs) from the lung cancer cell line CALU-1 in vitro. Cancer Cell Int. 2008; 8(1):17.
  • Miekisch W, Kischkel S, Sawacki A, Liebau T, Mieth M, Schubert JK. Impact of sampling procedures onto results of breath analysis. Impact of sampling procedures on the results of breath analysis. J Breath Res. 2008; 2: 026007 (7pp).
  • Miekisch W, Fuchs P, Kamysek S, Neumann C, Schubert JK. Assessment of propofol concentrations in human breath and blood by means of HS-SPME-GC-MS. Clin Chim Acta. 2008; 395(1-2):32-37.
  • Kushch I, Arendacka B, Stolc S, Mochalski P, Filipiak W, Schwarz K, Schwentner L, Schmid A, Dzien A, Lechleitner M, Witkovsky V, Miekisch W, Schubert JK, Unterkofler K and Amann A. Breath isoprene – aspects of normal physiology related to age, gender and cholesterol profile as determined in a proton transfer reaction mass spectrometry study. Clin Chem Lab Med 2008; 46:1011-8.
  • Thelen S; Miekisch W; Halmer D; Schubert JK; Hering P; Muertz M. Inter-comparison of infrared cavity leak-out spectroscopy and gas chromatography /Flame ionization for trace analysis of ethane. Anal Chem 2008; 80:2768 – 2773.
  • Pabst F, Miekisch W, Fuchs P, Kischkel S, Schubert JK. Monitoring of oxidative and metabolic stress during cardiac surgery by means of breath biomarkers: an observational study. J Cardiothor Surg 2007; 2:37.
  • Schubert JK, Miekisch W, Fuchs P, Scherzer N, Lord H, Pawliszyn J, Mundkowski RG. Determination of antibiotic drug concentrations in circulating human blood by means of solid phase micro-extraction. Clinica Chimica Acta 2007; 386:57–62.
  • Birken T, Schubert JK, Miekisch W, Nöldge-Schomburg GFE. A novel visually CO2 controlled alveolar breath sampling technique. Tech Health Care 2006; 14(6):499-506.
  • Mueller SC. Jolanta Majcher-Peszynska J. Uehleke B, Klammt S. Ralf G. Mundkowski RG. Miekisch W. Sievers H. Bauer S, Frank B, Kundt G. Drewelow B. The extent of induction of CYP3A by St. John’s wort varies among products and is linked to hyperforin dose. Eur J Clin Pharmacol 2006; 62:29-36.
  • Schubert JK, Miekisch W, Nöldge-Schomburg GFE. VOC breath markers in critically ill patients – potential and limitations. In: Breath analysis for clinical diagnostics and therapeutic monitoring. A Amann, D Smith Eds, World Scientific, London 2005, pp 267-92.
  • Schubert JK, Miekisch W, Birken T, Geiger K, Nöldge-Schomburg GFE. Impact of inspired substance concentrations onto results of breath analysis in mechanically ventilated patients. Biomarkers. 2005; 10:138-152.
  • Scholpp J, Schubert JK, Miekisch W, Noeldge-Schomburg GFE. Lipid peroxidation early after brain injury. J Neurotrauma. 2004; 21: 667-677.
  • Schubert JK, Miekisch W, Geiger K. Exhaled breath markers in ARDS. In: Lung Biology in Health and Disease. Disease Markers in Exhaled Breath. N Marczin, S Kharitonov Eds, Marcel Dekker, New York 01.10.2003, pp 363-80.
  • Schubert JK, Miekisch W, Nöldge-Schomburg GFE. Volatile organic compounds as prognostic markers in ARDS. In: Disease Markers in Exhaled Breath. Basic Mechanisms and Clinical Applications. N Marczin, MH Yacoub Eds, IOS Press NATO Science Series, Amsterdam 2002, pp 338-43.
  • Scholpp J, Schubert JK, Miekisch W, Geiger K. Breath markers and soluble lipid peroxidation markers in critically ill patients. Clin Chem Lab Med. 2002; 40:587-94.
  • Joarchi MS, Neiser U, Lenschow U, Schubert JK, Kienast W, Nöldge-Schomburg GFE, Steinhoff G. Thoratec left ventricular device for bridging to recovery in fulminant acute myocarditis. Ann Thorac Surg. 2002; 74:234-5.
  • Mols G, Hermle G, Schubert JK, Miekisch W, Benzing A, Geiger K. Volume-dependent compliance and VA/Q-mismatch in surfactant depleted isolated rabbit lungs. Crit Care Med. 2001; 29:144-51.
  • Schubert JK, Spittler K-H, Braun G, Geiger K, Guttmann J. CO2-controlled sampling of alveolar gas in mechanically ventilated patients. J Appl Physiol. 2001; 90:486-92.
  • Miekisch W, Schubert JK, Vagts D, Geiger K. Analysis of volatile disease markers in blood. Clin Chem. 2001; 47:1053-60.
  • Miekisch W, Schubert JK, Müller WPE, Geiger K. Analysis of Exhaled Air As a New Means of Critical Care Testing. In: Advances in Critical Care Testing. WF List, MM Müller, MJ McQueen Eds, Springer Verlag 1999, p 202.
  • Schubert JK, Esteban-Loos I, Geiger K, Guttmann J. In-vivo evaluation of a new method for chemical analysis of volatile components in the respiratory gas of mechanically ventilated patients. Technology and Healthcare. 1999; 7:29-37.
  • Müller WPE, Schubert JK, Benzing A, Geiger K. Method for the analysis of exhaled air by microwave energy desorption coupled with gas chromatography - flame ionisation detection – mass spectrometry. J Chromatogr B. 1998; 716:27-38.
  • Schubert JK, Müller WPE, Benzing A, Geiger K. Application of a new method for analysis of exhaled gas in critically ill patients. Intensive Care Med. 1998; 24:415-21.


Übersichtsartikel

  • Schubert JK, Geiger K. Bedeutung und Perspektiven der Atemgasanalytik
  • Anästhesiol Intensivmed Notfallmed Schmerzther 1999, 34:391-95.
  • Schubert JK, Nöldge-Schomburg GFE. Die Pneumonie beim Transplantatempfänger: Diagnostik, Prognose und klinisches Procedere Transplantlinc 2000 2:3-11.
  • Miekisch W, Schubert JK, Noeldge-Schomburg GFE. Diagnostic Potential of Breath Analysis - Focus on Volatile Organic Compounds Clin Chim Acta 2004, 347:25-39.
  • Schubert JK, Miekisch W, Geiger K, Nöldge-Schomburg GFE. Breath analysis in critically ill patients - potential and limitations Expert Rev Mol Diagn 2004, 4(5):89-99.
  • Miekisch W, Schubert JK. From highly sophisticated analytical techniques to life-saving diagnostics: Technical developments in breath analysis TrAC Trends in Analytical Chemistry 2006, 25: 665-673.
  • Schubert JK, Miekisch W, Fuchs P, Nöldge-Schomburg GFE. Analytical sciences and application in medicine – Dr Jekyll and Mr Hyde? The science and education in Europe. Proceedings of the VIP meeting of Societas Humboldtiana Polonorum, Torun 9 – 12 March 2006; 160-167.
  • Schubert JK. Nanoparticles in medicine – friends or foes? Nanotechnology: Development and influence on the society (Societas Humboldtiana Polonorum) Conference Proceedings, Gdansk 24 – 26 May 2007; 157-171.
  • Miekisch W, Trefz P, Bergmann A, Schubert JK. Microextraction techniques in breath biomarker analysis. Bioanalysis. 2014 May;6(9):1275-91.
  • Amann A, Costello Bde L, Miekisch W, Schubert J, Buszewski B, Pleil J, Ratcliffe N, Risby T. The human volatilome: volatile organic compounds (VOCs) in exhaled breath, skin emanations, urine, feces and saliva. J Breath Res. 2014 Sep;8(3):034001. doi: 10.1088/1752-7155/8/3/034001. Epub 2014 Jun 19. Review.
  • Amann A, Miekisch W, Schubert J, Buszewski B, Ligor T, Jezierski T, Pleil J, Risby T. Analysis of exhaled breath for disease detection. Annu Rev Anal Chem (Palo Alto Calif). 2014;7:455-82. doi: 10.1146/annurev-anchem-071213-020043


Buchbeiträge

  • Miekisch W, Schubert JK, Müller WPE, Geiger K. Analysis of Exhaled Air As a New Means of Critical Care Testing. In: Advances in Critical Care Testing. WF List, MM Müller, MJ McQueen Eds, Springer 1999, 202-211.
  • Schubert JK, Miekisch W, Nöldge-Schomburg GFE. Volatile organic compounds as prognostic markers in ARDS. In: Disease Markers in Exhaled Breath. Basic Mechanisms and Clinical Applications. N Marczin, MH Yacoub Eds, IOS Press NATO Science Series, Amsterdam 2002, 338-43.
  • Schubert JK, Miekisch W, Geiger K. Exhaled breath markers in ARDS. In: Lung Biology in Health and Disease. Disease Markers in Exhaled Breath. N Marczin, S Kharitonov Eds, Marcel Dekker, New York 2003, 363-80.
  • Schubert JK, Miekisch W, Nöldge-Schomburg GFE. VOC breath markers in critically ill patients – potential and limitations. In: Breath analysis for clinical diagnostics and therapeutic monitoring. A Amann, D Smith Eds, World Scientific, London 2005, 267-92.
  • Schubert JK. Pharmakologische Besonderheiten im Alter. In: Anästhesie 65 plus. A Benzing, T Loop Eds, Deutscher Ärzteverlag Köln 2009, 21-31.
  • Amann A, Miekisch W, Pleil J, Risby T, Schubert JK. Methodological issues of sample collection and analysis of exhaled breath. In: Exhaled Biomarkers. I Horvath, JC de Jongste Eds, European Respiratory Society Monograph, Vol. 49. 2010, 96-114.
  • Schubert JK, Miekisch W. Breath analysis in critically ill patients - potential and limitations. In: Volatile Biomarker. A Amann Ed., 2012, in press.